Yoshizumi M, Kitagawa T, Hori T, Katoh I, Houchi H, Ohuchi T, Oka M
Department of Cardiovascular Surgery and Pharmacology, School of Medicine, University of Tokushima, Japan.
Life Sci. 1996;59(4):324-30. doi: 10.1016/0024-3205(96)00301-3.
Sulfoconjugated catecholamines, especially dopamine sulfate, have recently attracted much attention because of the possibility of their conversion to active free dopamine by tissue arylsulfatase. In the present study, we have measured the plasma levels of free and sulfoconjugated dopamine in patients with hypertension and have investigated the physiological significance of sulfoconjugation. Results showed that the plasma level of dopamine sulfate in patients with essential hypertension was higher than the level in control subjects, and was highest in patients with renal hypertension. However, the plasma level of free dopamine showed no significant difference between patients with hypertension and normal subjects. Moreover, after normalization of blood pressure in hypertensive patients with medication, the plasma levels of conjugated dopamine decreased to almost the control value. In the experimental study, dopamine sulfate inhibited angiotensin II-induced aldosterone release from bovine adrenal cortical cells to a similar extent as produced by free dopamine. From these results, we have concluded that plasma sulfoconjugated dopamine may regulate free dopamine in the plasma of patients with hypertension, and it may have some physiological effects on blood pressure regulation.
硫酸结合儿茶酚胺，尤其是硫酸多巴胺，最近备受关注，因为它们有可能被组织芳基硫酸酯酶转化为活性游离多巴胺。在本研究中，我们测定了高血压患者血浆中游离和硫酸结合多巴胺的水平，并研究了硫酸结合的生理意义。结果显示，原发性高血压患者的硫酸多巴胺血浆水平高于对照组，肾性高血压患者的该水平最高。然而，高血压患者与正常受试者的游离多巴胺血浆水平无显著差异。此外，高血压患者药物治疗使血压正常化后，结合多巴胺的血浆水平降至几乎与对照值相同。在实验研究中，硫酸多巴胺抑制血管紧张素II诱导的牛肾上腺皮质细胞醛固酮释放的程度与游离多巴胺相似。根据这些结果，我们得出结论，血浆硫酸结合多巴胺可能调节高血压患者血浆中的游离多巴胺，并且可能对血压调节有一些生理作用。
