Mori H, Oda M, Mizuno Y
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Neurosci Lett. 1996 May 10;209(2):109-12. doi: 10.1016/0304-3940(96)12612-4.
We report the presence of ballooned neurons (BNs) in the cerebral cortex of patients with progressive supranuclear palsy (PSP) using immunohistochemistry for phosphorylated neurofilament in addition to standard histologic staining methods. In six of the nine patients studied. BNs were seen in the cerebral cortex. In two of these six patients. BNs were abundant and cortical degeneration was present in the precentral cortex. On immunohistochemistry. BNs were positive for phosphorylated neurofilament and alpha B crystallin, and some BNs were positive for ubiquitin and tau protein. The immunohistochemical staining pattern was similar to that of the BNs seen in other diseases, such as corticobasal degeneration. The presence of cortical BNs does not differentiate PSP from corticobasal degeneration although BNs are fewer in the patients with PSP when cortical degeneration is not present.
我们运用磷酸化神经丝免疫组织化学方法以及标准组织学染色方法，报告了进行性核上性麻痹（PSP）患者大脑皮质中气球样神经元（BNs）的存在情况。在所研究的9例患者中，有6例在大脑皮质中发现了BNs。在这6例患者中的2例，BNs数量丰富，中央前回皮质存在皮质变性。免疫组织化学显示，BNs对磷酸化神经丝和αB晶状体蛋白呈阳性反应，部分BNs对泛素和tau蛋白也呈阳性反应。免疫组织化学染色模式与在其他疾病（如皮质基底节变性）中所见的BNs相似。尽管在无皮质变性的PSP患者中BNs数量较少，但皮质BNs的存在并不能将PSP与皮质基底节变性区分开来。
