Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H
Department of Orthopedic Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Neurosci Lett. 1996 May 24;210(1):45-8. doi: 10.1016/0304-3940(96)12659-8.
Corticospinal volleys and surface electromyographic (EMG) responses evoked by magnetic and electrical transcranial stimulation were recorded simultaneously in three conscious human subjects. For magnetic stimulation, the figure-of-eight coil was held on the hand motor area either with the induced current through the brain flowing in a postero-anterior direction (P-A stimulation) or in a latero-medial direction (L-M stimulation). For electrical stimulation, the anode was placed 7 cm lateral to the vertex and cathode at the vertex (anodal stimulation). The P-A stimulation that was generally used preferentially evoked I waves, whereas the L-M and anodal stimulation preferentially evoked D wave. The results suggested that the mode of activation by transcranial magnetic stimulation altered, depending on its current direction, and the difference between P-M magnetic and electrical stimulation can be explained by the context of the D and I hypothesis.
在三名清醒的人类受试者中，同时记录了磁刺激和电刺激诱发的皮质脊髓冲动以及表面肌电图（EMG）反应。对于磁刺激，将八字形线圈置于手部运动区，感应电流通过大脑的方向分别为后向前（P-A刺激）或外侧向内侧（L-M刺激）。对于电刺激，将阳极置于头顶外侧7厘米处，阴极置于头顶（阳极刺激）。通常优先使用的P-A刺激优先诱发I波，而L-M刺激和阳极刺激优先诱发D波。结果表明，经颅磁刺激的激活模式会根据其电流方向而改变，P-M磁刺激和电刺激之间的差异可以用D波和I波假说的背景来解释。
