Frances Y, Lafay V, Madona O, Chastang C, Souchet T, Chazelle F
Service de Médecine Interne et Urgences, CHU Nord, Marseille, France.
Therapie. 1996 Jan-Feb;51(1):35-9.
The combination of two antihypertensive drugs is recommended when mild to moderate hypertension is not controlled by sequential monotherapy. The aim of our study was to compare the efficacy and the safety of the combination enalapril 20 mg-hydrochlorothiazide 12.5 mg to that of enalapril 20 mg-nifedipine SL 20 mg x 2. Two hundred and forty four hypertensive patients not controlled (DPB > 95 mmHg) by a single dose of enalapril 20 mg/24 h, received for 4 weeks, one of these two combined therapies in a randomized double-blind trial. The efficacy was of same amplitude in the two groups (DBP: -10.8 mmHg enalapril-hydrochlorothiazide vs-10.3 mmHg enalapril-nifedipine). The side effects were less frequent in the enalapril-hydrochlorothiazide group (14 per cent vs 24 per cent, p = 0.04).
当轻度至中度高血压通过序贯单一疗法无法控制时，推荐联合使用两种抗高血压药物。我们研究的目的是比较依那普利20毫克-氢氯噻嗪12.5毫克组合与依那普利20毫克-硝苯地平舌下含服20毫克×2的疗效和安全性。244例单剂量依那普利20毫克/24小时治疗未得到控制（舒张压>95毫米汞柱）的高血压患者，在一项随机双盲试验中接受这两种联合疗法之一治疗4周。两组的疗效幅度相同（舒张压：依那普利-氢氯噻嗪组降低10.8毫米汞柱，依那普利-硝苯地平组降低10.3毫米汞柱）。依那普利-氢氯噻嗪组的副作用发生率较低（14%对24%，p = 0.04）。
