Thomas P, Giudicelli R, Fuentes P, Reboud E
Service de Chirurgie Thoracique et des Maladies de l'OEsophage, Hôpital Sainte-Marguerite, MARSEILLE.
Ann Chir. 1996;50(2):106-20.
From 1985 to 1995, 60 patients with a mean age of 52 +/- 12 years [24-78] underwent colon interposition for esophageal replacement. Indications were esophageal cancer (n = 37), benign stricture (n = 13), iatrogenic esophageal fistula (n = 5), achalasia with megaesophagus (n = 3), and necrosis of a previous substitute (n = 2). Colon interposition represented only 18.5% of all operations performed for oesophageal replacement during the same period. The colon was selected because of inadequate stomach in 33 cases (55%). Long-segment conduit based on the ascending branch of the left colonic artery was the preferred method and could be used in 52 patients (86.7%). The colon was placed in the esophageal bed in 38 patients (63.3%), substernally in 21 (35%), and subcutaneously in 1. Overall operative mortality and morbidity were 8.3% and 65% respectively. Five-year survival rate was 9% in the 37 patients with esophageal cancer. Seven patients (13.5%) required one or more dilatations of the esophagocolonic anastomosis. At last follow-up, 34 patients (65.4%) had no difficulty eating. Multivariate analysis identified the conduit position in the posterior mediastinum as an independent predictor of good functional result (p = 0.0018). We conclude that colon interposition for esophageal replacement provides satisfactory and durable function; however, early mortality and morbidity are substantial.
1985年至1995年期间,60例平均年龄为52±12岁(24 - 78岁)的患者接受了结肠代食管术以替代食管。手术适应证包括食管癌(n = 37)、良性狭窄(n = 13)、医源性食管瘘(n = 5)、贲门失弛缓症合并巨食管(n = 3)以及既往替代物坏死(n = 2)。在同一时期,结肠代食管术仅占所有食管替代手术的18.5%。33例(55%)患者因胃条件不佳而选择结肠。以左结肠动脉升支为基础的长段管道是首选方法,52例患者(86.7%)适用。38例患者(63.3%)将结肠置于食管床内,21例(35%)置于胸骨后,1例置于皮下。总体手术死亡率和发病率分别为8.3%和65%。37例食管癌患者的5年生存率为9%。7例患者(13.5%)需要对食管结肠吻合口进行一次或多次扩张。在最后一次随访时,34例患者(65.4%)进食无困难。多因素分析确定后纵隔内管道位置是功能良好结果的独立预测因素(p = 0.0018)。我们得出结论,结肠代食管术可提供令人满意且持久的功能;然而,早期死亡率和发病率较高。