[Effects of (-) SPD and (-) THP on the firing of noradrenergic neurons in locus coeruleus].
作者信息
Wu J H, Jin G Z
机构信息
Shanghaai Institute of Materia Medica, Chinese Academy of Sciences.
出版信息
Sheng Li Xue Bao. 1995 Dec;47(6):601-4.
PMID:8762452
Abstract
The effects of (-) SPD and (-) THP on the noradrenergic neurons in rat locus coeruleus were investigated by recording the in vivo spontaneous firing. It was found that (-) SPD could increase the firing frequency of the NE neurons via antagonistic action on alpha 2 autoreceptors in a dose-dependent manner, while alpha 2 receptor agonist clonidine exerted an inhibitory effect. (-) THP induced inhibitory firing of the neurons, however, irreversible.
摘要
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