Lu W, Chen Y, Chen C
Burn Institute, Changhai Hospital, Shanghai.
Zhonghua Wai Ke Za Zhi. 1995 Dec;33(12):745-8.
Delayed fluid resuscitation of burn shock may lead to many harmful effects. We investigated the injury of liver and kidney of rats sustaining non-fluid perfusion, immediate perfusion, and delayed perfusion of burn shock. The electron spin reonance (ESR) was used to determine the existence of oxygen free radicals (OFR) successfully. We tested the activity of ATP enzyme in kidney, lactate dehydrogenase isoenzyme 5 (LDH5), GPT and GOT. We also tested the contents of malonaldehyde (MDA) and ATP in liver and kidney, urea nitrogen (BUN) and creatinine (Cr) in blood. We found that OFR plays an important role in the injury of liver and kidney sustaining delayed fluid resuscitation of burn shock. Immediate fluid perfusion can not protect the liver and kidney perfectely. And some OFR scavengers should be added to the fluid resuscitation of burn shock.
烧伤休克延迟液体复苏可能会导致许多有害影响。我们研究了非液体灌注、即刻灌注和烧伤休克延迟灌注的大鼠的肝、肾损伤情况。成功地使用电子自旋共振（ESR）来测定氧自由基（OFR）的存在。我们检测了肾中ATP酶的活性、乳酸脱氢酶同工酶5（LDH5）、谷丙转氨酶（GPT）和谷草转氨酶（GOT）。我们还检测了肝、肾中丙二醛（MDA）和ATP的含量，血液中尿素氮（BUN）和肌酐（Cr）的含量。我们发现OFR在烧伤休克延迟液体复苏所致的肝、肾损伤中起重要作用。即刻液体灌注并不能完全保护肝和肾。并且应该在烧伤休克的液体复苏中添加一些OFR清除剂。
