Tanaka S, Braga I S, Kimura T, Ochiai K, Itakura C, Mizutani M
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Comp Pathol. 1996 Apr;114(3):325-37. doi: 10.1016/s0021-9975(96)80054-5.
Ultrastructural study of muscles taken from a mutant (LWC) strain of Japanese quail with myotonia showed type 2 fibre atrophy, ring fibre formation, sarcoplasmic masses, and "moth-eaten" fibres. In these abnormal fibres, the most characteristic feature was the loss of interconnection among the myofibrils, mitochondria, and T tubules. Apparently normal muscle fibres often showed mild changes, such as proliferation of T tubules and enlarged sarcoplasmic areas with increased glycogen granules and ribosomes at the periphery of the fibres. The study suggested that one possible cause of these ultrastructural changes was a defect in cytoskeleton of muscle cells, especially in intermediate filaments.
对患有肌强直的日本鹌鹑突变体（LWC）品系的肌肉进行的超微结构研究显示，2型纤维萎缩、环形纤维形成、肌浆块和“虫蚀状”纤维。在这些异常纤维中，最典型的特征是肌原纤维、线粒体和T小管之间的连接丧失。看似正常的肌纤维常常表现出轻微变化，如T小管增生以及肌浆区域扩大，纤维周边糖原颗粒和核糖体增多。该研究表明，这些超微结构变化的一个可能原因是肌肉细胞细胞骨架的缺陷，尤其是中间丝的缺陷。
