Binkert F, Schmid W
Mutat Res. 1977 Apr;46(2):63-75. doi: 10.1016/0165-1161(77)90113-3.
Karyotyes were determined in 226 pre-implantation embryos (4--8-cell stages) of Chinese hamster. The study was carried out under controlled natural breeding conditions, without superovulation and with the embryos developing in their mothers. A total of 5.3% karyotypically abnormal embryos were found. Over half, 3.1%, were due to ploidy mutations, 5 cases of triploidy and 2 cases of haploidy. Only 0.9% genome mutations were present, consisting of one autosomal trisomy and one autosomal monosomy. Structural aberrations were found in 1.8%, half of these probably due to a balanced maternal aberration and the rest appearing the mosaic condition only. These results are compared with the scarce body of mammalian data from the literature. Compared with the situation in man, the spontaneous aberration rates in the Chinese hamster and other experimental mammals are extremely low. This may be due, in part, to optimal timing of copulation in respect to estrus and ovulation prevailing in these animals but not in man. The low spontaneous aberration rate in the reported system is a valuable asset for purposes of mutagen testing.
对中国仓鼠226个植入前胚胎（4-8细胞阶段）进行了核型分析。该研究在自然繁殖控制条件下进行，未进行超排卵，胚胎在母体内发育。共发现5.3%的核型异常胚胎。超过一半，即3.1%，是由于倍性突变，5例三倍体和2例单倍体。仅存在0.9%的基因组突变，包括1例常染色体三体和1例常染色体单体。发现1.8%存在结构畸变，其中一半可能是由于母体平衡畸变，其余仅表现为嵌合状态。将这些结果与文献中稀少的哺乳动物数据进行了比较。与人类情况相比，中国仓鼠和其他实验哺乳动物的自发畸变率极低。这可能部分归因于这些动物中交配相对于发情和排卵的最佳时间，而人类则不然。所报道系统中低自发畸变率对于诱变测试而言是一项宝贵资产。
