Dayan C, Guilding T, Hearing S, Thomas P, Nelson R, Moss T, Bradshaw J, Levy A, Lightman S
University Department of Medicine, Bristol Royal Infirmary, UK.
Clin Endocrinol (Oxf). 1996 May;44(5):597-602. doi: 10.1046/j.1365-2265.1996.685507.x.
Pituitary carcinoma with metastatic endocrine secreting tissue is rare. Eight cases of malignant, growth hormone-secreting tumours, all metastatic within the central nervous system have been previously described. Complete surgical resection was not possible and the patients died within 4 years of presentation with distant spread. Here we describe the first case of an apparent surgical cure of a somatotroph carcinoma metastatic to the cervical spine, documented by biochemical assessment and magnetic resonance and radioligand imaging. The possibility that intrathecal metastasis of somatotroph tumours may be responsible for some cases of treatment resistant acromegaly is discussed.
伴有转移性内分泌分泌组织的垂体癌很罕见。此前已报道过8例恶性生长激素分泌性肿瘤，均在中枢神经系统内发生转移。无法进行完整的手术切除，患者在出现远处转移后的4年内死亡。在此，我们描述了首例经生化评估、磁共振成像和放射性配体成像证实的生长激素细胞癌转移至颈椎且实现了明显手术治愈的病例。文中还讨论了生长激素细胞肿瘤的鞘内转移可能是某些难治性肢端肥大症病例病因的可能性。
