Eulry F, Mayaudon H, Bauduceau B, Lechevalier D, Crozes P, Magnin J, Claude-Berthelot C
Service de Rhumatologie, Hôpital d'Instruction des Armées Bégin, Saint-Mandé.
Ann Med Interne (Paris). 1996;147(1):15-9.
Prolactin radioimmunoassay was carried out before and 15, then 30 min after intravenous infusion of protireline (0.2 mg) in 3 groups of male patients: 7 with reactive arthritis (HLA B27: 6; age: 25 +/- 6.3 yr), 13 with ankylosing spondylitis (HLA B27: 11; age: 33.2 +/- 14.7 yr), 5 with psoriatic arthritis (HLA B27: 1; age: 28.8 +/- 6.3 yr). The same test was carried out in sex-age-body mass index matched controls. Only the patients with reactive arthritis presented dynamic hyperprolactinaemia 15 and 30 min after protireline infusion and none of ankylosing or psoriatic arthritis groups. A complete failure of bromocriptine was observed in reactive arthritis. In 2 cases of psoriatic arthritis, adding bromocriptine to gold salts and nonsteroidal anti-inflammatory drug was followed by a drastic efficacy with spectacular improvement in clinical, biological and occupational status. Because none of the cases had hyperprolactinaemia, bromocriptine acted probably had an intrinic anti-inflammatory effect independent of its antiprolactinic effect.
7例反应性关节炎患者（HLA B27阳性：6例；年龄：25±6.3岁）、13例强直性脊柱炎患者（HLA B27阳性：11例；年龄：33.2±14.7岁）、5例银屑病关节炎患者（HLA B27阳性：1例；年龄：28.8±6.3岁）。在静脉输注普罗瑞林（0.2mg）前、输注后15分钟及30分钟分别进行测定。对年龄、性别、体重指数匹配的对照组进行了同样的检测。只有反应性关节炎患者在输注普罗瑞林后15分钟及30分钟出现动态高催乳素血症，强直性脊柱炎组和银屑病关节炎组均未出现。在反应性关节炎患者中观察到溴隐亭完全无效。在2例银屑病关节炎患者中，在金盐和非甾体抗炎药基础上加用溴隐亭后，临床、生物学和职业状况均有显著改善，疗效显著。由于所有病例均无高催乳素血症，溴隐亭可能发挥了与其抗催乳素作用无关的内在抗炎作用。
