Nour S, MacKinnon A E, Dickson J A, Walker J
Children's Hospital, Sheffield, UK.
J R Coll Surg Edinb. 1996 Jun;41(3):178-80.
A retrospective study of 50 patients with infantile hypertrophic pyloric stenosis (IHPS) showed wound infection in six patients. In an attempt to assess the value of antibiotic prophylaxis in infantile pyloromyotomy 150 patients with infantile hypertrophic pyloric stenosis were entered in a prospective randomized controlled study. The infants were allocated to receive a dose of Cefuroxime (30 mg/kg) at induction of anaesthesia or no antibiotic. Eight infants developed wound infection, five in the control group and three in the antibiotic prophylaxis group. Although the difference between the two groups was not statistically significant there was an overall reduction of wound infection (6.5%) compared with pre-trial figures (12%). In order to study the bacterial flora in the umbilicus in these infants, culture swabs were taken from the umbilicus on admission, immediately prior to surgery and from the wound prior to skin closure. It was shown that the umbilicus was not the source of infection.
一项对50例婴儿肥厚性幽门狭窄（IHPS）患者的回顾性研究显示，有6例患者出现伤口感染。为了评估抗生素预防在婴儿幽门肌切开术中的价值，150例婴儿肥厚性幽门狭窄患者进入一项前瞻性随机对照研究。这些婴儿被分配在麻醉诱导时接受一剂头孢呋辛（30mg/kg）或不使用抗生素。8例婴儿出现伤口感染，5例在对照组，3例在抗生素预防组。尽管两组之间的差异无统计学意义，但与试验前数据（12%）相比，伤口感染总体有所减少（6.5%）。为了研究这些婴儿脐部的细菌菌群，在入院时、手术即将开始前以及皮肤缝合前从伤口处采集脐部培养拭子。结果表明，脐部不是感染源。
