Novelli M, Savoia P, Fierro M T, Verrone A, Quaglino P, Bernengo M G
Clinica Dermatologica I dell'Università di Torino, Italy.
Br J Dermatol. 1996 Jun;134(6):1052-6.
CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.
运用免疫组化技术研究了正常和病理皮肤中角质形成细胞上CD26的表达情况。在正常皮肤中发现散在局灶性CD26阳性，而在皮肤T细胞淋巴瘤以及炎症性皮肤病如银屑病、扁平苔藓和海绵状皮炎的基底和棘层中观察到CD26表达增加。CD26角质形成细胞染色并非某一种疾病所特有，而是似乎与表皮中反应性或肿瘤性浸润的存在相关。我们提出CD26分子可能作为一种角质形成细胞活化抗原发挥作用。
