Bagot M, Charue D, Boulland M L, Gaulard P, Revuz J, Schmitt C, Wechsler J
Department of Dermatology, University Paris XII, Hôpital Henri Mondor, Créteil, France.
Br J Dermatol. 1996 Oct;135(4):572-5.
Keratinocyte-derived interleukin-7 (IL-) is a potent growth factor for some cutaneous T-cell lymphomas (CTCL). We investigated the expression of IL-7 receptor (IL-7R) in several types of cutaneous and nodal lymphomas. We studied 44 CTCL (13 mycosis fungoides, six Sézary syndromes, eight pleomorphic small cell, and 17 pleomorphic medium and large cell), 10 lymphomatoid papulosis (LP), five cutaneous B-cell lymphomas, and five reactive lymphocytic infiltrates. Twenty nodal T-cell lymphomas, and three reactive lymph nodes were also analysed. Frozen sections were stained with monoclonal antibodies directed against IL-7R, CD25, CD30 and T antigens (CD3, CD2, CD5, CD7, CD4, CD8), using the alkaline phosphatase-antialkaline phosphatase technique. No expression of IL-7R was observed in cutaneous B-cell lymphomas, benign cutaneous lymphoid infiltrates, and reactive lymph nodes. IL-7R was expressed by more than 20% of lymphoid cells in 50-75% of all histological subtypes of CTCL, and by more than 50% of cells in 15-50%. IL-7R was expressed by more than 20% and 50% of cells in 40% and 10% of nodal large T-cell lymphomas, respectively. Eighty-nine per cent of CTCL and LP expressing IL7-R also expressed CD25+, compared with 58% of IL-7R--CTCL and LP (P < 0.05). No association of IL7-R and CD30 expression was found. In conclusion, CTCL frequently express IL-7R. This expression is not related to the epidermotropic characteristic of the infiltrate. In CTCL and LP, IL-7R expression is associated to CD25 expression, but not to CD30 expression.
角质形成细胞衍生的白细胞介素-7（IL-7）是某些皮肤T细胞淋巴瘤（CTCL）的一种强效生长因子。我们研究了IL-7受体（IL-7R）在几种皮肤和淋巴结淋巴瘤中的表达情况。我们研究了44例CTCL（13例蕈样肉芽肿、6例Sezary综合征、8例多形性小细胞型以及17例多形性中、大细胞型）、10例淋巴瘤样丘疹病（LP）、5例皮肤B细胞淋巴瘤以及5例反应性淋巴细胞浸润。还分析了20例淋巴结T细胞淋巴瘤以及3个反应性淋巴结。采用碱性磷酸酶-抗碱性磷酸酶技术，用针对IL-7R、CD25、CD30和T抗原（CD3、CD2、CD5、CD7、CD4、CD8）的单克隆抗体对冰冻切片进行染色。在皮肤B细胞淋巴瘤、良性皮肤淋巴细胞浸润以及反应性淋巴结中未观察到IL-7R的表达。在所有组织学亚型的CTCL中，50%-75%的病例中超过20%的淋巴细胞表达IL-7R，15%-50%的病例中超过50%的细胞表达IL-7R。在40%的淋巴结大T细胞淋巴瘤中，分别有超过20%和50%的细胞表达IL-7R。表达IL-7R的CTCL和LP中89%也表达CD25+，而IL-7R阴性的CTCL和LP中这一比例为58%（P<0.05）。未发现IL-7R与CD30表达之间存在关联。总之，CTCL经常表达IL-7R。这种表达与浸润的亲表皮特征无关。在CTCL和LP中，IL-7R表达与CD25表达相关，但与CD30表达无关。
