Novel PTS proteins revealed by bacterial genome sequencing: a unique fructose-specific phosphoryl transfer protein with two HPr-like domains in Haemophilus influenzae.

The completely sequenced genome of Haemophilus influenzae has been analysed for proteins of the phosphoenolpyruvate: sugar phosphotransferase system (PTS). We show that within the fructose PTS H. influenzae possesses a novel multi-domain phosphoryl transfer protein, not previously recognized, that includes two fructose-specific HPr domains fused in tandem in a single polypeptide chain.