Dreher W H, Zimmerman S W, Simpson D P
Nephron. 1977;18(6):321-5. doi: 10.1159/000180850.
16 patients with membranoproliferative glomerulonephritis had a mean serum chloride level significantly higher than that in normal subjects or in comparable groups of patients with nephrotic syndrome secondary to either systemic lupus erythematosus or to other primary nephrotic glomerular diseases. Differences in the severity of histologic alterations of the renal interstitium did not correlate with the different levels of serum chloride seen in these groups. The increased chloride concentration may be partially explained as a compensating reaction for a decrease in protein anions. However, a renal tubular acidifying defect demonstrated in one of our patients may also contribute to the hyperchloremia in some cases.
16例膜增生性肾小球肾炎患者的平均血清氯水平显著高于正常受试者或患有系统性红斑狼疮继发肾病综合征或其他原发性肾病性肾小球疾病的可比患者组。肾间质组织学改变严重程度的差异与这些组中不同的血清氯水平无关。氯化物浓度升高可能部分解释为对蛋白质阴离子减少的一种代偿反应。然而，我们的一名患者所表现出的肾小管酸化缺陷在某些情况下也可能导致高氯血症。
