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多发性硬化症病变的磁共振成像。治疗试验中的疗效评估。

Magnetic resonance imaging of multiple sclerosis lesions. Measuring outcome in treatment trials.

作者信息

Simon J H

机构信息

Department of Radiology, University of Colorado Health Sciences Center, Denver 80262, USA.

出版信息

West J Med. 1996 Jun;164(6):502-9.

PMID:8764625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1303626/
Abstract

Magnetic resonance-based measures of disease activity and progression are now routinely used in definitive phase III treatment trials of multiple sclerosis as important secondary outcome measures because they provide quantitative and objective confirmation of the primary clinical outcome measures. Magnetic resonance-based activity measures can also be used as an efficient mechanism for screening therapies in phase I and II trials. In this review I consider the natural history of multiple sclerosis lesions and the relationships between magnetic resonance measures and clinical observations of disease as the basis for the use of magnetic resonance markers in current and future treatment trials.

摘要

基于磁共振的疾病活动和进展测量方法，如今在多发性硬化症的确定性III期治疗试验中作为重要的次要结局指标被常规使用，因为它们为主要临床结局指标提供了定量且客观的确认。基于磁共振的活动测量方法还可作为I期和II期试验中筛选疗法的有效机制。在这篇综述中，我将多发性硬化症病变的自然史以及磁共振测量与疾病临床观察之间的关系视为在当前和未来治疗试验中使用磁共振标志物的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2f/1303626/df7a09299fea/westjmed00357-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2f/1303626/3cdfdd71c32d/westjmed00357-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2f/1303626/df7a09299fea/westjmed00357-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2f/1303626/3cdfdd71c32d/westjmed00357-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2f/1303626/df7a09299fea/westjmed00357-0040-b.jpg

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引用本文的文献

1
Magnetic resonance imaging in clinical therapeutic trials of multiple sclerosis.多发性硬化症临床治疗试验中的磁共振成像
West J Med. 1996 Jun;164(6):531-2.

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