Höltje J V
Max-Planck-Institut für Entwicklungsbiologie, Abteilung Biochemie, Tübingen, Germany.
EXS. 1996;75:65-74. doi: 10.1007/978-3-0348-9225-4_4.
Lysozymes are found in many bacteria that are surrounded by a murein-(peptidoglycan) containing cell wall. Their physiological function for the bacteria is still a matter of debate. On the one hand they can autolyse the cell, on the other hand they may have an essential role during enlargement and division of the cell wall by the controlled splitting of bonds in the murein sacculus. Both beta-1.4-N,6-O-diacetylmuramidase and beta-1.4-N-acetylmuramidases have been described in bacteria. In some cases a modular design of the enzyme has been demonstrated with a catalytic domain and a substrate (murein)-binding and recognition domain consisting of repeated motifs.
溶菌酶存在于许多被含有胞壁质（肽聚糖）的细胞壁所包围的细菌中。它们对细菌的生理功能仍是一个有争议的问题。一方面，它们可以自溶细胞，另一方面，它们可能在细胞壁通过控制胞壁质囊泡中键的断裂进行扩大和分裂的过程中发挥重要作用。β-1,4-N,6-O-二乙酰胞壁酸酶和β-1,4-N-乙酰胞壁酸酶在细菌中均有描述。在某些情况下，已证明该酶具有模块化设计，包括一个催化结构域和一个由重复基序组成的底物（胞壁质）结合和识别结构域。
