帕金森病和帕金森叠加综合征患者的磁共振断层扫描
[Magnetic resonance tomography in patients with Parkinson's disease and Parkinson-plus syndromes].
作者信息
Hierholzer J, Schrag A, Cordes M, Sander B, Schelosky L, Harisch C, Venz S, Keske U, Mäurer J, Poewe W, Felix R
机构信息
Strahlenklinik und Poliklinik, Humboldt-Universität Berlin.
出版信息
Rofo. 1996 Jul;165(1):43-51. doi: 10.1055/s-2007-1015712.
PURPOSE
To define characteristic MR-findings in patients with clinically typical extrapyramidal movement disorders.
METHODS
15 patients with Parkinson's disease (PD), 9 with multisystem atrophy (MSA), and 6 with progressive supranuclear palsy (PSP) underwent MRI using a 1.5 T. Magnetom unit. Two investigators analysed the images with special regard to global and/or focal atrophy and to changes in signal intensity of the CNS in the consensus mode. Normal images of 10 subjects served as controls to patient's images.
RESULTS
In all patients with PSP and MSA characteristic pathological findings on MRI were observed including regional changes within the extrapyramidal nuclei. In contrast all patients with PD had an unremarkable MRI study of the CNS.
CONCLUSION
MRI enables us to define characteristic morphological changes of the brain in patients with extrapyramidal movement disorders. Early recognition of these findings avoids misdiagnoses in patients who are difficult to diagnose.
目的
明确临床典型锥体外系运动障碍患者的特征性磁共振成像（MR）表现。
方法
15例帕金森病（PD）患者、9例多系统萎缩（MSA）患者和6例进行性核上性麻痹（PSP）患者使用1.5T Magnetom设备进行了MRI检查。两名研究人员以共识模式分析图像，特别关注整体和/或局灶性萎缩以及中枢神经系统（CNS）信号强度的变化。10名受试者的正常图像作为患者图像的对照。
结果
在所有PSP和MSA患者中均观察到MRI上的特征性病理表现，包括锥体外系核内的区域变化。相比之下，所有PD患者的CNS的MRI检查均无明显异常。
结论
MRI使我们能够明确锥体外系运动障碍患者大脑的特征性形态学变化。早期识别这些表现可避免对难以诊断的患者进行误诊。
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