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(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.

作者信息

Cosford N D, Bleicher L, Herbaut A, McCallum J S, Vernier J M, Dawson H, Whitten J P, Adams P, Chavez-Noriega L, Correa L D, Crona J H, Mahaffy L S, Menzaghi F, Rao T S, Reid R, Sacaan A I, Santori E, Stauderman K A, Whelan K, Lloyd G K, McDonald I A

机构信息

SIBIA Neurosciences Inc., La Jolla, California 92037, USA.

出版信息

J Med Chem. 1996 Aug 16;39(17):3235-7. doi: 10.1021/jm960328w.

DOI:10.1021/jm960328w
PMID:8765504
Abstract
摘要

相似文献

1
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
J Med Chem. 1996 Aug 16;39(17):3235-7. doi: 10.1021/jm960328w.
2
Expedient five-step synthesis of SIB-1508Y from natural nicotine.从天然尼古丁快速五步合成SIB-1508Y。
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Effects of SIB-1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys.新型神经元烟碱型乙酰胆碱受体激动剂SIB-1508Y对帕金森病猴运动行为的影响。
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Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist.新型烟碱型乙酰胆碱受体激动剂（S）-（2）-5-乙炔基-3-（1-甲基-2-吡咯烷基）吡啶盐酸盐（SIB-1508Y，阿替林可）的药理学特性
Brain Res. 2008 Oct 9;1234:16-24. doi: 10.1016/j.brainres.2008.07.063. Epub 2008 Jul 28.
5
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.(R)-5-(2-氮杂环丁烷基甲氧基)-2-氯吡啶（ABT-594）的鉴定及初步构效关系，ABT-594是一种强效、口服活性、通过神经元烟碱型乙酰胆碱受体起作用的非阿片类镇痛药。
J Med Chem. 1998 Feb 12;41(4):407-12. doi: 10.1021/jm9706224.
6
4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors.4-[[2-(1-甲基-2-吡咯烷基)乙基]硫代]苯酚盐酸盐（SIB-1553A）：一种对神经元烟碱型乙酰胆碱受体具有选择性的新型认知增强剂。
J Med Chem. 1999 May 20;42(10):1684-6. doi: 10.1021/jm990035d.
7
5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.6-卤代-3-((2-(S)-氮杂环丁烷基)甲氧基)吡啶和6-卤代-3-((2-(S)-吡咯烷基)甲氧基)吡啶的5-取代衍生物，对α4β2烟碱型乙酰胆碱受体具有低皮摩尔亲和力且亲脂性范围广：正电子发射断层扫描成像的潜在探针
J Med Chem. 2004 May 6;47(10):2453-65. doi: 10.1021/jm030432v.
8
5-I A-85380 and TC-2559 differentially activate heterologously expressed alpha4beta2 nicotinic receptors.5 - I A - 85380和TC - 2559对异源表达的α4β2烟碱型受体的激活作用存在差异。
Eur J Pharmacol. 2006 Jun 6;539(1-2):10-7. doi: 10.1016/j.ejphar.2006.03.077. Epub 2006 Apr 5.
9
Effects of the nicotinic acetylcholine receptor agonist SIB-1508Y on object retrieval performance in MPTP-treated monkeys: comparison with levodopa treatment.烟碱型乙酰胆碱受体激动剂SIB-1508Y对MPTP处理的猴子物体取回能力的影响：与左旋多巴治疗的比较。
Ann Neurol. 1998 Mar;43(3):311-7. doi: 10.1002/ana.410430308.
10
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.新型的埃博霉素吡啶环C5取代类似物和3-(1-甲基-2(S)-吡咯烷基甲氧基)吡啶(A-84543)作为含β2亚基的神经元烟碱型乙酰胆碱受体的高选择性药物。
J Med Chem. 2005 Mar 24;48(6):1721-4. doi: 10.1021/jm0492406.

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