Djaldetti R, Hart J, Alexandrova S, Cohen S, Beilin B, Djaldetti M, Bessler H
Department of Neurology, Beilinson Medical Center, Petah Tiqva, Israel.
J Submicrosc Cytol Pathol. 1996 Jul;28(3):319-23.
The present study was undertaken to examine the effect of 2-CdA (Leustatin) on the Schwann cells of myelinated and unmyelinated fibers of peripheral mouse nerve. Two groups of mice were injected intravenously for seven days with 2-CdA: one group received daily doses of 1 mg/kg and the other 0.5 mg/kg. Both doses exceeded those accepted in clinical practice. Mice injected with saline served as controls. The sciatic nerve was then dissected and examined with a transmission electron microscope. The Schwann cells of both the myelinated and unmyelinated nerve fibers of the animals receiving the higher doses of 2-CdA showed nuclear and nucleolus damage, loss of heterochromatin, vacuolization and disorganization of the myelin sheaths. The mesaxons and the axons were also damaged. The Schwann cells of the animals treated with the lower doses appeared undamaged. The results indicate that in contrast to other anticancer drugs known to produce peripheral neuropathy, 2-CdA may cause damage to the Schwann cells only at doses exceeding the therapeutic ones.
本研究旨在探讨2-氯脱氧腺苷（Leustatin）对小鼠外周神经有髓和无髓纤维雪旺细胞的影响。两组小鼠静脉注射2-氯脱氧腺苷，持续7天：一组每日剂量为1mg/kg，另一组为0.5mg/kg。这两种剂量均超过了临床实践中认可的剂量。注射生理盐水的小鼠作为对照。然后解剖坐骨神经，用透射电子显微镜进行检查。接受较高剂量2-氯脱氧腺苷的动物的有髓和无髓神经纤维的雪旺细胞均显示出核仁和核损伤、异染色质丢失、空泡化以及髓鞘紊乱。中轴突和轴突也受到了损伤。接受较低剂量治疗的动物的雪旺细胞似乎未受损。结果表明，与已知会导致周围神经病变的其他抗癌药物不同，2-氯脱氧腺苷可能仅在超过治疗剂量时才会对雪旺细胞造成损伤。
