Department of Cranio-Maxillofacial Surgery, University Hospital, Bern, Switzerland.
J Oral Pathol Med. 2012 Mar;41(3):268-71. doi: 10.1111/j.1600-0714.2011.01098.x. Epub 2011 Nov 18.
The aim of this study was to investigate the histomorphological changes of the infraorbital nerve of rats treated with ampicillin.
The infraorbital nerve was approached through the infraorbital foramen, and 0.01 ml of ampicillin dissolved in distilled water was injected taking care not to damage the nerve. Saline solution was used in control animals. Nerves were dissected and after routine histology processing analysed by light microscopy.
Cross-section of the nerve treated with ampicillin showed damaged axons with disintegration of heavily myelinated fibres, while thinly myelinated fibres remain unaffected. In the saline group, no damage was observed. The signs of regeneration of the damaged infraorbital nerves were detected on the fourth post-operative week.
Ampicillin can cause peripheral nerve damage when injected perineurally.
本研究旨在探讨氨苄青霉素治疗后大鼠眶下神经的组织形态学变化。
通过眶下孔接近眶下神经，并小心地注入 0.01 毫升溶于蒸馏水的氨苄青霉素，注意不要损伤神经。在对照组动物中使用生理盐水。分离神经，经过常规组织学处理后，在光镜下进行分析。
用氨苄青霉素处理的神经的横截面显示受损的轴突，有髓纤维严重崩解，而薄髓纤维不受影响。在盐水组中，没有观察到损伤。在术后第四周检测到受损的眶下神经的再生迹象。
经神经周围注射氨苄青霉素可引起周围神经损伤。
