小鼠脯氨酰二肽酶cDNA的克隆：脯氨酰二肽酶mRNA在肾脏中的优势表达
Cloning of mouse prolidase cDNA: predominant expression of prolidase mRNA in kidney.
作者信息
Ishii T, Tsujino S, Matsunobu S, Endo F, Sato K, Sakuragawa N
机构信息
Department of Inherited Metabolic Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
出版信息
Biochim Biophys Acta. 1996 Jul 31;1308(1):15-6. doi: 10.1016/0167-4781(96)00084-x.
PMID:8765744
Abstract
We cloned mouse prolidase cDNA from a mouse liver cDNA library. Homology to human prolidase is 83.2% at the nucleotide level and 87.2% at the amino acid level. Northern blot analysis showed that while prolidase mRNA was transcribed in brain, heart, liver, and muscle, it was predominantly transcribed in kidney.
摘要
我们从小鼠肝脏cDNA文库中克隆了小鼠脯氨酰二肽酶cDNA。其与人类脯氨酰二肽酶在核苷酸水平上的同源性为83.2%，在氨基酸水平上为87.2%。Northern印迹分析表明，虽然脯氨酰二肽酶mRNA在脑、心脏、肝脏和肌肉中均有转录，但主要在肾脏中转录。
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