Weindler J, Rippa A, Kiefer T, Burg A, Ruprecht K W
Augenklinik und Poliklinik, Universität des Saarlandes.
Klin Monbl Augenheilkd. 1996 May;208(5):410-3. doi: 10.1055/s-2008-1035255.
In the present clinical study, oral premedication of 0.15 mg clonidine has been explored with view to anxiolytic effects and physiological stress parameters.
The study involved 44 patients of ASA-class I-III, all scheduled to undergo ophthalmological surgery under retrobulbar anesthesia (RBA). One hour before RBA 22 patients received 0.15 mg clonidine and 22 patients placebo p.o. The following parameters were assessed at different times perioperatively: oxygenation (SpO2), heart rate, blood pressure, intraocular pressure and anxiety. Anxiolysis was determined using the Erlanger Anxiety Scale.
There were no significant differences among the groups in SpO2 and heart rate. Significantly decreased blood pressures were measured after clonidine premedication (p < 0.01). In contrast to clonidine after placebo the preoperative anxiety increased. Right before operation anxiety was decreased significantly (p < 0.01) by clonidine compared to placebo.
In our opinion, oral clonidine (0.15 mg) is useful for premedication of surgery under RBA.
在本临床研究中，探讨了口服0.15毫克可乐定的抗焦虑作用及生理应激参数。
该研究纳入44例ASA I-III级患者，均计划在球后麻醉（RBA）下行眼科手术。在RBA前1小时，22例患者口服0.15毫克可乐定，22例患者口服安慰剂。在围手术期不同时间评估以下参数：氧合（SpO2）、心率、血压、眼压及焦虑程度。使用埃尔朗格焦虑量表测定抗焦虑效果。
两组患者的SpO2和心率无显著差异。可乐定预处理后血压显著降低（p < 0.01）。与可乐定相反，安慰剂组术前焦虑增加。与安慰剂相比，术前即刻可乐定显著降低了焦虑程度（p < 0.01）。
我们认为，口服可乐定（0.15毫克）对RBA下手术的预处理有用。
