吡唑并[1,5 - a]吡啶并[3,4 - e]嘧啶 - 6 - 酮。I. 合成及体外抗菌活性评价
Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. I. Synthesis and in vitro antimicrobial evaluation.
作者信息
Bruni F, Selleri S, Costanzo A, Guerrini G, Casilli M L, Sacco C, Donato R
机构信息
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Firenze, Italy.
出版信息
Farmaco. 1996 Jun;51(6):451-5.
PMID:8766231
Abstract
A series of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones (9-36) was prepared by a simple synthetic procedure based on the reaction of ethyl 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates (1-8) and reagents (a-n) containing a primary amino group. When this set of compounds was subjected to "in vitro" antimicrobial screening, it showed no significant activity.
摘要
通过基于7-二甲基氨基乙烯基吡唑并[1,5-a]嘧啶-6-羧酸乙酯（1-8）与含伯氨基的试剂（a-n）的反应的简单合成方法，制备了一系列吡唑并[1,5-a]吡啶并[3,4-e]嘧啶-6-酮（9-36）。当对这组化合物进行“体外”抗菌筛选时，未显示出显著活性。
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