Wakui S, Furusato M, Sasaki S, Masaoka T, Ushigome S, Aizawa S
Comparative Toxicology Laboratories, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
Anat Histol Embryol. 1996 Jun;25(2):109-11. doi: 10.1111/j.1439-0264.1996.tb00066.x.
Epidermal growth-factor receptor (EGF-r), a membrane-bound glycoprotein activated by EGF, is important in maintaining the integrity and function of the prostate. To investigate EGF-r presence in the prostate of the rhesus monkey, monoclonal-antibody immunohistochemical examination was performed. The monkey prostate consisted of the cranial and caudal lobes, and the prostatic epithelial cells were composed of the secretory and basal cells. The distribution patterns of EGF-r in the prostatic epithelial cells were quite different between the cranial and caudal lobes. In the caudal lobe, EGF-r was seen in both secretory and basal cells, whereas, in the cranial lobe, the EGF-r was seen exclusively in the basal cells. The stromal cells of both lobes did not show EGF-r. This study revealed that each prostatic lobe contains specific binding sites for EGF, indicating a biological difference between the two lobes of the prostate of the rhesus monkey.
表皮生长因子受体（EGF-r）是一种由表皮生长因子激活的膜结合糖蛋白，对维持前列腺的完整性和功能很重要。为了研究恒河猴前列腺中EGF-r的存在情况，进行了单克隆抗体免疫组化检查。恒河猴前列腺由头叶和尾叶组成，前列腺上皮细胞由分泌细胞和基底细胞组成。EGF-r在前列腺上皮细胞中的分布模式在头叶和尾叶之间有很大差异。在尾叶中，分泌细胞和基底细胞中均可见EGF-r，而在头叶中，EGF-r仅见于基底细胞。两叶的基质细胞均未显示EGF-r。这项研究表明，每个前列腺叶都含有EGF的特异性结合位点，这表明恒河猴前列腺两叶之间存在生物学差异。
