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[感染人类免疫缺陷病毒的女性的上生殖道感染:流行病学、诊断及治疗方面]

[Upper genital tract infections in women infected with HIV: epidemiologic, diagnostic and therapeutic aspects].

作者信息

Panel P, Benifla J L, Darai E, Renolleau C, Sebban E, Waschowska B, Madelenat P

机构信息

Service de Gynécologie-Obstétrique, CHU Bichat-Claude-Bernard, Paris.

出版信息

Contracept Fertil Sex. 1996 Jun;24(6):488-94.

PMID:8766512
Abstract

Fifty seven women hospitalized in the gynecological department of Bichat-Claude Bernard hospital in Paris for pelvic inflammatory disease (PID) proven by laparoscopy from sept. 1992 to nov. 1994 had a serological diagnosis of HIV infection. Three of them (5,2%) were positive (HIV+). Previous publications have shown from 4% to 17% in the USA and as much as 32% in Abidjan. However this prevalence is arising each year. PID in HIV+ seems to have more often a poor symptomatology but require more surgical treatments. Postpartum endometritis in HIV+ were also studied. From 1989 to 1994, we observed 109 delivery in HIV+ patients. Numerous infectious diseases occurred but endometritis were not significantly elevated. Three american studies in HIV+ failed to show an increased risk of postpartum endometritis but a fourth larger study achieved in Abidjan, showed a significantly higher risk of endometritis, associated with decreasing levels of CD4. HIV+ women are at increased risk of upper genital tract infection and could profit from obstetrical antibioprophylaxis.

摘要

1992年9月至1994年11月期间,在巴黎比夏-克劳德·贝尔纳医院妇科住院的57名因腹腔镜检查证实患有盆腔炎(PID)的女性接受了HIV感染的血清学诊断。其中3人(5.2%)呈阳性(HIV+)。此前美国的出版物显示感染率为4%至17%,在阿比让则高达32%。然而,这种患病率每年都在上升。HIV+患者的PID似乎症状往往较轻,但需要更多的手术治疗。我们还对HIV+患者的产后子宫内膜炎进行了研究。1989年至1994年,我们观察了109例HIV+患者的分娩情况。发生了许多传染病,但子宫内膜炎并未显著增加。美国三项针对HIV+患者的研究未显示产后子宫内膜炎风险增加,但在阿比让进行的第四项规模更大的研究显示,子宫内膜炎风险显著更高,且与CD4水平下降有关。HIV+女性发生上生殖道感染的风险增加,可从产科抗生素预防中获益。

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