Förstl H, Geiger-Kabisch C, Sattel H, Besthorn C, Schreiter-Gasser U, Abrahams C M, Biedert S
Psychiatrische Klinik, Zentralinstitut für Seelische Gesundheit, Mannheim.
Fortschr Neurol Psychiatr. 1996 Jun;64(6):228-33. doi: 10.1055/s-2007-996390.
The correlations between (a) the patients' memory complaints, (b) the informants' rating of the patients' cognitive impairment, and (c) cognitive performance according to the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) were examined in 163 patients with probable or possible Alzheimer's disease. The patients' complaints were weakly correlated with informants' view (p < 0.05), closely correlated with depressive mood (p < 0.0001), but not with cognitive performance or the stage of dementia. The results of Clinical Dementia Rating, Mini-Mental State Examination and the Cambridge Cognitive Examination were significantly correlated with the informants' rating of cognitive impairment (p < 0.0001). These results are in line with previous studies and confirm (1) the suitability of CAMDEX for the structured examination of dementia patients and their caregivers, (2) the association between affective disturbances and the perception of cognitive deficits, and (3) the importance informants' rating for the valid evaluation of demented patients.
在163例可能或疑似患有阿尔茨海默病的患者中，研究了以下三者之间的相关性：(a)患者的记忆主诉；(b) Informant对患者认知障碍的评分；(c) 根据老年精神障碍剑桥检查（CAMDEX）得出的认知表现。患者的主诉与Informant的看法呈弱相关（p < 0.05），与抑郁情绪密切相关（p < 0.0001），但与认知表现或痴呆阶段无关。临床痴呆评定量表、简易精神状态检查和剑桥认知检查的结果与Informant对认知障碍的评分显著相关（p < 0.0001）。这些结果与先前的研究一致，并证实了(1) CAMDEX适用于对痴呆患者及其照料者进行结构化检查；(2) 情感障碍与认知缺陷感知之间的关联；(3) Informant评分对于有效评估痴呆患者的重要性。
