Verdoux H, Bourgeois M
IPSO, Centre Carreire, Université de Bordeaux II, Service Universitaire de Psychiatrie.
Encephale. 1996 Jun;22 Spec No 2:45-7.
Risk factors promoting the occurrence of neuroleptic-related tardive dyskinesia remain poorly understood. It has been hypothesized that type II schizophrenia, based on Crow's classification, would be more liable to this complication due to cerebral structural abnormalities involved in the pathogenesis of schizophrenia characterized by deficitary symptoms. Association between tardive dyskinesia and cognitive deficit is currently the most firmly established. Data in the literature concerning the association between tardive dyskinesia and the other features of type II schizophrenia are more contradictory.
促进抗精神病药物相关迟发性运动障碍发生的危险因素仍未得到充分了解。据推测，根据克劳的分类，II型精神分裂症由于以阴性症状为特征的精神分裂症发病机制中涉及的脑结构异常，更容易出现这种并发症。迟发性运动障碍与认知缺陷之间的关联目前是最确凿的。文献中关于迟发性运动障碍与II型精神分裂症其他特征之间关联的数据则更具矛盾性。
