6,7-二芳基蝶啶的驱虫活性。
Anthelmintic activity of 6,7-diaryl-pteridines.
作者信息
Ochoa C, Rodríguez J, López García M L, Ramón Martínez A, Mercedes Martínez M
机构信息
Instituto de Quimica Medico, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
出版信息
Arzneimittelforschung. 1996 Jun;46(6):643-8.
PMID:8767359
Abstract
In a search for new anthelmintic compounds, some 6,7-diaryl-pteridines were synthesized from the corresponding diaminopyrimidines and aromatic aldehydes. Their anthelmintic activity was tested in vitro against Caenorhabditis elegans and Heligmosomoides polygyrus and in vivo against Trichinella spiralis. Structure-activity relationships are discussed.
摘要
为了寻找新的驱虫化合物，从相应的二氨基嘧啶和芳香醛合成了约6,7-二芳基蝶啶。对其驱虫活性进行了体外抗秀丽隐杆线虫和多枝海德线虫以及体内抗旋毛虫的测试。并讨论了构效关系。
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