Verhoeven A J, Jansen H
Department of Biochemistry, Erasmus University Rotterdam, The Netherlands.
Z Gastroenterol. 1996 Jun;34 Suppl 3:54-5.
Besides in liver, hepatic lipase (HL) activity is present in adrenals, ovaries and testes where it may play a role in the delivery of HDL cholesterol required for steroidogenesis. The full-length mRNA coding for HL is only expressed in liver. In rat steroidogenic organs, the HL gene is transcribed into a truncated mRNA that lacks the first two coding exons, and which may be translated into a non-secretable 40 kDa protein cross-reacting with anti-HL antibodies. This raises questions about the tissue-specific transcription of the HL gene into two different mRNA's, and the possible function of the 40 kDa protein. Finally, it leaves the problem how the steroidogenic organs acquire the liver-derived HL activity.
除肝脏外，肝脂酶（HL）活性还存在于肾上腺、卵巢和睾丸中，在这些器官中它可能在类固醇生成所需的高密度脂蛋白胆固醇传递过程中发挥作用。编码HL的全长mRNA仅在肝脏中表达。在大鼠类固醇生成器官中，HL基因转录成一种截短的mRNA，该mRNA缺少前两个编码外显子，并且可能被翻译成一种与抗HL抗体发生交叉反应的不可分泌的40 kDa蛋白质。这就引发了关于HL基因在组织特异性转录为两种不同mRNA以及40 kDa蛋白质可能功能的问题。最后，这也留下了类固醇生成器官如何获得肝脏来源的HL活性这一问题。
