Wenzel K W
Rudolf Virchow University Hospital, Department of Medicine, Free University of Berlin, Germany.
Acta Med Austriaca. 1996;23(1-2):57-60.
Commonly prescribed drugs can variously cause changes in measuring serum T3 and T4 concentrations. Thus spuriously normal thyroid hormone levels may result in moderate hypo- or hyperthyroidism, or the influence of pharmacological substances may lead to a false diagnosis of thyroid disease in euthyroid subjects. On the other hand numerous pharmacological agents, especially those interacting with neurotransmitters, may influence TSH secretion, too. While generally such drug-induced abnormal thyroid tests do not correspond to clinical features of thyroid dysfunction, iodine containing drugs, especially amiodarone, may result in overt thyroid disease.
常用药物可能会以多种方式导致血清T3和T4浓度测量值发生变化。因此，甲状腺激素水平假性正常可能会导致中度甲状腺功能减退或亢进，或者药物物质的影响可能会导致甲状腺功能正常的受试者被误诊为甲状腺疾病。另一方面，许多药物制剂，尤其是那些与神经递质相互作用的药物，也可能影响促甲状腺激素（TSH）的分泌。虽然一般来说，这种药物引起的甲状腺检查异常与甲状腺功能障碍的临床特征不相符，但含碘药物，尤其是胺碘酮，可能会导致明显的甲状腺疾病。
