Tidholm A, Karlsson I, Wallius B
Djursjukhuset Albano-Animal Hospital of Stockholm, Danderyd, Sweden.
Acta Vet Scand. 1996;37(2):213-7. doi: 10.1186/BF03548113.
Pansteatitis (yellow fat disease, panniculitis, steatitis) is an inflammatory disease of adipose tissue throughout the body 1987). It was first experimentally induced by in 1946 in cats fed a diet deficient in vita-min E and high in cod liver oil 1946). It has since been reported as a clinical condition by several authors 1953, 1973, 1975, 1982, 1986). Pansteatitis occurs naturally in cats, mink, and pigs as a result of vitamin E E (α-tocopherol) is a biological antioxidant found in vegetable oils 1987). It serves as a protector of the fats in the diet and in the body. Pansteatitis is caused by a mismatch between intake of unsaturated fatty acids and antioxidants, i.e. vitamin E. The ensu-ing peroxidation of the body fat causes a for-eign body reaction with severe inflammation and cell death. The foremost clinical sign is hy-peraesthesia or severe pain on palpation/han-dling, especially over the back and of the abdo-men. The final diagnosis rests with the histo-logical findings of the above-mentioned lesions in conjunction with acid-fast ceroid pigment (i.e. end-product of lipid peroxidation) in fat cells, in macrophages, in Langhans-type giant cells, and extracellularly 1987).
全脂炎（黄色脂肪病、脂膜炎、脂肪炎）是一种累及全身脂肪组织的炎症性疾病（1987年）。1946年，它首次在实验中被诱导产生，当时给猫喂食缺乏维生素E且富含鱼肝油的饮食（1946年）。此后，有几位作者将其报道为一种临床病症（1953年、1973年、1975年、1982年、1986年）。全脂炎在猫、水貂和猪中自然发生，是维生素E缺乏的结果。维生素E（α-生育酚）是一种存在于植物油中的生物抗氧化剂（1987年）。它可保护饮食和体内的脂肪。全脂炎是由不饱和脂肪酸与抗氧化剂（即维生素E）摄入不匹配引起的。随后体内脂肪的过氧化会引发异物反应，伴有严重炎症和细胞死亡。最主要的临床症状是感觉过敏或触诊/处理时剧痛，尤其是背部和腹部。最终诊断取决于上述病变的组织学发现，以及脂肪细胞、巨噬细胞、朗汉斯型巨细胞内和细胞外的耐酸性类蜡样色素（即脂质过氧化的终产物）（1987年）。
