用单克隆抗CD4抗体治疗预防肥胖品系（OS）鸡的自发性自身免疫性甲状腺炎。

Prevention of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by treatment with a monoclonal anti-CD4 antibody.

作者信息

Cihak J, Hoffmann-Fezer G, Wasl M, Merkle H, Kaspers B, Hála K, Plachý J, Wick G

机构信息

Institute of Animal Physiology, University of Munich, Federal Republic of Germany.

出版信息

Zentralbl Veterinarmed A. 1996 Jun;43(4):211-6. doi: 10.1111/j.1439-0442.1996.tb00446.x.

DOI:10.1111/j.1439-0442.1996.tb00446.x

PMID:8767730

Abstract

Untreated control OS chickens develop spontaneous autoimmune thyroiditis (SAT). In contrast, OS chickens treated with a monoclonal anti-CD4 antibody failed to develop SAT. The preventive effect of anti-CD4 antibody on SAT was associated with the marked depletion of CD4+ T-cells by anti-CD4 treatment. These results indicate that CD4+ T-cells play a crucial role in SAT of OS chickens.

摘要

未经治疗的对照OS鸡会发生自发性自身免疫性甲状腺炎（SAT）。相比之下，用单克隆抗CD4抗体治疗的OS鸡未发生SAT。抗CD4抗体对SAT的预防作用与抗CD4治疗导致的CD4 + T细胞显著耗竭有关。这些结果表明，CD4 + T细胞在OS鸡的SAT中起关键作用。