Ki-Zerbo G A, Sawadogo A, Millogo A, Andonaba J B, Yameogo A, Ouedraogo I, Tamini M, Konate B, Durand G
Service de Médecine Interne, I'Hôpital National Souro Sanou, Bobo-Dioulasso, Burkina Faso.
Med Trop (Mars). 1996;56(1):63-5.
The authors report five cases of Cryptococcus neoformans meningitis in HIV-positive patients hospitalized in the Souro Sanou National Hospital Center of Bobo-Dioulasso (Burkina Faso). There were 3 men and 2 women with a mean age of 36 years (range: 29 to 47 years). Presenting symptoms were persistent headache and/or mental confusion and neurosensory defects. Cerebrospinal fluid was clear with less than 20 lymphocytes/mm3. Albumin concentration greater than 0.50 g/l was observed in only one case. India ink smear and culture demonstrated strains of Cryptococcus neoformans sensitive to amphotericin B in all five cases, flucytosin in 3 cases, and ketoconazole in two cases. Four patients died within 15 to 32 days after admission (mean 22.5 days). Delayed diagnosis and inconsistent availability of systemic antifungal drugs are major limiting factors in the management of Cryptococcus neoformans meningitis in Burkina Faso.
作者报告了在布瓦迪乌拉索（布基纳法索）苏罗萨努国家医院中心住院的5例HIV阳性患者的新型隐球菌性脑膜炎病例。其中有3名男性和2名女性，平均年龄为36岁（范围：29至47岁）。呈现的症状为持续性头痛和/或精神错乱以及神经感觉缺陷。脑脊液清澈，淋巴细胞少于20/mm³。仅1例观察到白蛋白浓度大于0.50g/l。印度墨汁涂片和培养显示，所有5例中的新型隐球菌菌株对两性霉素B敏感，3例对氟胞嘧啶敏感，2例对酮康唑敏感。4例患者在入院后15至32天内死亡（平均22.5天）。延迟诊断和全身性抗真菌药物供应不稳定是布基纳法索新型隐球菌性脑膜炎治疗中的主要限制因素。
