Feldmeier H, Nass R, Strasburger C J
Klinikum Innenstadt der Ludwig-Maximilians-Universität München.
Fortschr Med. 1996 Jun 10;114(16):205-9.
Human growth hormone (GH) is produced in the anterior lobe of the pituitary gland not only in childhood but also in the adult. It has an influence on the physical performance, composition and metabolism of the adult organism. A complex system of endocrine and paracrine factors mediate the influence of growth hormone, and its deficiency in the adult leads to such typical clinical symptoms as fatigue, a lack of drive, poor physical performance and truncal obesity. Since recombinant human growth hormone can now be produced by gene technology in unlimited amounts, it has become possible to investigate new indications for growth hormone therapy in adults. GH replacement has recently become an accepted form of treatment of patients with proven GH deficiency after controlled clinical trials had shown it to have beneficial results.
人生长激素（GH）不仅在儿童期，而且在成年期都由垂体前叶分泌。它对成年生物体的身体机能、组成和新陈代谢有影响。一个由内分泌和旁分泌因子组成的复杂系统介导生长激素的作用，而其在成年人中的缺乏会导致疲劳、缺乏动力、身体机能不佳和躯干肥胖等典型临床症状。由于现在可以通过基因技术无限量生产重组人生长激素，因此研究生长激素在成人中的新适应症成为可能。在对照临床试验显示生长激素替代疗法有有益结果后，GH替代疗法最近已成为治疗已证实的GH缺乏患者的一种被认可的治疗方式。
