Grassi M, Schiffino L, Messini F, Villani A R, Spada S
Istituto di Idrologia Medica, Università degli Studi di Roma La Sapienza.
Clin Ter. 1996 Mar;147(3):117-22.
In this research we evaluated the prevalence of Hp in the gastric mucosa in patients suffering for chronic liver disease, either chronic hepatitis or liver cirrhosis. Sixty-three patients 27 with chronic hepatitis and 36 with liver cirrhosis, were examined by EGDS; of them we evaluated: endoscopic findings of stomach and duodenum, histology of gastric mucosa (antrum and corpus-fundus), presence of Hp in the histologic samples. We compared the positivity for Hp with the following parameters: presence of esophageal varices, macroscopic aspect of the gastric and duodenal mucosa, presence of hystological findings of gastritis, gastritis's activity, grading of the hepatic damage. In the our research we didn't point out greater prevalence of the Hp in the gastric mucosa with respect to hepatic damage, esophageal varices or macroscopic signs of gastric pathology. The Hp is significantly associated with histologic evidence of gastritis and also with the grade of gastritis's activity. The data of the present work don't suggest any correlation within the pathologic changes of the gastric mucosa caused from the liver cirrhosis and the presence or the growth of Hp.
在本研究中,我们评估了慢性肝病(包括慢性肝炎或肝硬化)患者胃黏膜中幽门螺杆菌(Hp)的感染率。63例患者(27例慢性肝炎患者和36例肝硬化患者)接受了电子胃镜检查(EGDS);对他们进行了以下评估:胃和十二指肠的内镜检查结果、胃黏膜(胃窦和胃体-胃底)组织学检查、组织学样本中Hp的存在情况。我们将Hp阳性与以下参数进行了比较:食管静脉曲张的存在、胃和十二指肠黏膜的宏观表现、胃炎组织学表现的存在、胃炎的活动度、肝损伤分级。在我们的研究中,未发现相对于肝损伤、食管静脉曲张或胃病理学宏观体征而言,胃黏膜中Hp感染率更高。Hp与胃炎的组织学证据以及胃炎的活动度分级显著相关。本研究数据未提示肝硬化引起的胃黏膜病理变化与Hp的存在或生长之间存在任何相关性。