Gavilán Carrasco J C, González Santos P, Rosario Díaz E
Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Málaga.
Rev Clin Esp. 1996 May;196(5):277-80.
The use of non-specific markers before 1989 (increased serum transaminase values and antibodies to hepatitis B core antigen) as a screening method for blood donors in an attempt to decrease the incidence of post-transfusional non-A non-B hepatitis (currently hepatitis C virus) was a matter of controversy. To determine the impact of the use of these markers on the detection of blood donors infected with hepatitis C virus, a prospective study was undertaken in Málaga (1988-1989) with 5,003 volunteer donors with two objectives: a) to know the prevalence of these non-specific markers (anti-HBc and increased serum transaminase) and antibodies to HCV (anti-C100) in our blood donor population; b) to determine whether the presence of some of these non specific markers in blood donors was associated with a higher rate of virus C infection. The prevalence of antibodies to HCV in blood donors with increased serum transaminase and/or anti-HBc was significantly higher than the prevalence found among the general blood donor population.
1989年以前，使用非特异性标志物（血清转氨酶值升高和抗乙型肝炎核心抗原抗体）作为献血者筛查方法，试图降低输血后非甲非乙型肝炎（目前为丙型肝炎病毒）的发病率，这是一个有争议的问题。为了确定使用这些标志物对检测感染丙型肝炎病毒的献血者的影响，1988 - 1989年在马拉加对5003名志愿献血者进行了一项前瞻性研究，有两个目的：a）了解这些非特异性标志物（抗-HBc和血清转氨酶升高）以及抗HCV抗体（抗-C100）在我们献血人群中的流行情况；b）确定献血者中某些非特异性标志物的存在是否与丙型肝炎病毒感染率较高有关。血清转氨酶升高和/或抗-HBc的献血者中抗HCV抗体的流行率明显高于普通献血人群中的流行率。
