翻译起始因子eIF-2B在哺乳动物细胞蛋白质合成调控中的作用。 - Suppr

Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells.

作者信息

Kimball S R, Mellor H, Flowers K M, Jefferson L S

机构信息

Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033, USA.

出版信息

Prog Nucleic Acid Res Mol Biol. 1996;54:165-96. doi: 10.1016/s0079-6603(08)60363-3.

DOI:10.1016/s0079-6603(08)60363-3

PMID:8768075

Abstract

摘要

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Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells.翻译起始因子eIF-2B在哺乳动物细胞蛋白质合成调控中的作用。

Prog Nucleic Acid Res Mol Biol. 1996;54:165-96. doi: 10.1016/s0079-6603(08)60363-3.

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.酵母鸟嘌呤核苷酸交换因子eIF-2B的GCD7亚基中的突变克服了磷酸化eIF-2对翻译起始的抑制作用。

Mol Cell Biol. 1994 May;14(5):3208-22. doi: 10.1128/mcb.14.5.3208-3222.1994.

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.有证据表明，GCN4的翻译调节因子GCD6和GCD7是酿酒酵母中eIF-2的鸟嘌呤核苷酸交换因子的亚基。

Mol Cell Biol. 1993 Mar;13(3):1920-32. doi: 10.1128/mcb.13.3.1920-1932.1993.

Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation.真核生物翻译起始因子2（eIF-2α）α亚基中的突变可克服eIF-2α磷酸化对翻译起始的抑制作用。

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7215-9. doi: 10.1073/pnas.90.15.7215.

Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B.

Proc Natl Acad Sci U S A. 1995 May 9;92(10):4274-8. doi: 10.1073/pnas.92.10.4274.

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast.GCN4 mRNA翻译调控因子的一种蛋白质复合物是酵母中翻译起始因子2的鸟嘌呤核苷酸交换因子。

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5350-4. doi: 10.1073/pnas.90.11.5350.

Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3.酿酒酵母中真核生物翻译起始因子2的鸟嘌呤核苷酸交换因子：必需亚基GCD2、GCD6和GCD7与调节亚基GCN3之间的相互作用

Mol Cell Biol. 1993 Aug;13(8):4618-31. doi: 10.1128/mcb.13.8.4618-4631.1993.

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.哺乳动物真核生物起始因子2α激酶在酵母的GCN4翻译控制机制中功能上替代了GCN2蛋白激酶。

Proc Natl Acad Sci U S A. 1993 May 15;90(10):4616-20. doi: 10.1073/pnas.90.10.4616.

Cloning and expression of cDNAs for the beta subunit of eukaryotic initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic initiation factor-2.真核起始因子-2B的β亚基（真核起始因子-2的鸟嘌呤核苷酸交换因子）的cDNA克隆与表达

Biochem J. 1995 Aug 1;309 ( Pt 3)(Pt 3):1009-14. doi: 10.1042/bj3091009.

The guanine nucleotide-exchange factor, eIF-2B.鸟嘌呤核苷酸交换因子，真核起始因子2B。

Biochimie. 1994;76(8):748-60. doi: 10.1016/0300-9084(94)90079-5.

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Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes.不同的真核生物起始因子2Bε突变导致少突胶质细胞对内质网应激的不同程度不耐受。

Chin Med J (Engl). 2015 Jul 5;128(13):1772-7. doi: 10.4103/0366-6999.159353.

Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway.氨基酸剥夺通过 GCN2/ATF4 通路促进肿瘤血管生成。

Neoplasia. 2013 Aug;15(8):989-97. doi: 10.1593/neo.13262.

The amino terminus of the vaccinia virus E3 protein is necessary to inhibit the interferon response.痘苗病毒 E3 蛋白的氨基末端对于抑制干扰素反应是必需的。

J Virol. 2012 May;86(10):5895-904. doi: 10.1128/JVI.06889-11. Epub 2012 Mar 14.

A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.翻译起始因子2B中的一个点突变导致少突胶质细胞源性细胞持续处于高应激状态。

PLoS One. 2008;3(11):e3783. doi: 10.1371/journal.pone.0003783. Epub 2008 Nov 21.

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.GCN2 eIF2α激酶是小鼠适应氨基酸剥夺所必需的。

Mol Cell Biol. 2002 Oct;22(19):6681-8. doi: 10.1128/MCB.22.19.6681-6688.2002.

Inactivation of eukaryotic initiation factor 2B in vitro by heat shock.体外热休克使真核生物起始因子2B失活。

Biochem J. 1998 Sep 1;334 ( Pt 2)(Pt 2):463-7. doi: 10.1042/bj3340463.

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Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells.

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