[关于工作场所空气中吡罗昔康最低肺泡有效浓度依据的实验数据]
[Experimental data on bases of MAC of piroxicam in the air of workplace].
作者信息
Bogachuk G P, Barkova N P, Andropova S N, Gushchina A A, Portianoĭ A A
出版信息
Med Tr Prom Ekol. 1996(4):26-8.
PMID:8768116
Abstract
The experiments on white rats, mice, guinea pigs, rabbits studied inhalation toxicity of piroxicam. The substance having strong cumulation (Jcum = 0.5) and embryotoxic effects (Limap = 0.1 mg/cum) is assigned to a group of parenchymatous poisons. Toxicometry data (CL50 = 250 mg/cum, Limac = 50 mg/cum, Limch = 0.5 mg/cum) prove the first jeopardy grade of the substance. The recommended MAC for workplace is 0.05 mg/cum.
摘要
对白鼠、小鼠、豚鼠和兔子进行的实验研究了吡罗昔康的吸入毒性。该物质具有很强的蓄积性（Jcum = 0.5）和胚胎毒性作用（Limap = 0.1毫克/立方米），被归为实质性毒物类别。毒理学数据（CL50 = 250毫克/立方米，Limac = 50毫克/立方米，Limch = 0.5毫克/立方米）证明该物质属于一级危险等级。工作场所推荐的最大容许浓度为0.05毫克/立方米。
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