Fisman S, Steele M, Short J, Byrne T, Lavallee C
Division of Child and Adolescent Psychiatry, Children's Hospital of Western Ontario, London, Canada.
J Am Acad Child Adolesc Psychiatry. 1996 Jul;35(7):937-40. doi: 10.1097/00004583-199607000-00021.
The development of anorexia nervosa in a high-functioning, early adolescent, autistic female is described. This case raises the issue of co-occurrence of childhood-onset disorders sharing the phenomena of obsessions and compulsions. The role of dysregulation of the serotonergic neurotransmitter system as a common underlying mechanism in these disorders is suggested. Psychoactive agents affecting the serotonin system and in particular the atypical neuroleptic risperidone may be of value in these disorders. There is added benefit to the combined use of biological and behavioral therapies.
本文描述了一名高功能、青春期早期的自闭症女性神经性厌食症的发展情况。该病例引发了儿童期起病的疾病共病现象中存在强迫观念和强迫行为的问题。文中指出血清素能神经递质系统失调作为这些疾病共同潜在机制的作用。影响血清素系统的精神活性药物,尤其是非典型抗精神病药物利培酮,可能对这些疾病有治疗价值。生物疗法和行为疗法联合使用有额外的益处。