Zuskin E, Kanceljak B, Sarić M, Mustajbegović J, Bradić V
Skola narodnog zdravlja Andrija Stampar, Medicinskog fakulteta Sveucilista u Zagrebu.
Arh Hig Rada Toksikol. 1996 Mar;47(1):57-67.
The effects of organic aerosols (coffee, teas, spices, confectionery, soy, animal feed) on the respiratory system of workers occupationally exposed to these aerosols are presented. Described are possible mechanisms responsible for the development of respiratory impairment. Our studies indicate the possibility of development of respiratory impairment in exposed workers. The prevalence of chronic respiratory symptoms and diseases varied from 2.7 to 56.3% and of acute symptoms from 9.9 to 78.9% of exposed workers. Statistically significant acute reductions of ventilatory capacity (FVC, FEV1, FEF50, FEF25) were recorded during the work shift. Described are some immunological changes which can develop in exposure to organic aerosols. Experimental studies with water organic dust extracts on isolated guinea pig trachea suggest that bronchoconstrictive changes in humans may be reproduced in non-sensitized guinea pigs. The need for taking preventive medical examinations in order to prevent development of respiratory and/or immunological impairment is stressed.
本文介绍了有机气溶胶（咖啡、茶、香料、糖果、大豆、动物饲料）对职业接触这些气溶胶的工人呼吸系统的影响。描述了导致呼吸功能损害的可能机制。我们的研究表明，接触气溶胶的工人有可能出现呼吸功能损害。接触工人慢性呼吸道症状和疾病的患病率在2.7%至56.3%之间，急性症状的患病率在9.9%至78.9%之间。在工作班次期间，记录到通气能力（用力肺活量、第一秒用力呼气量、50%用力呼气流量、25%用力呼气流量）有统计学意义的急性下降。描述了接触有机气溶胶时可能出现的一些免疫变化。用水性有机粉尘提取物对离体豚鼠气管进行的实验研究表明，未致敏的豚鼠可能会重现人类的支气管收缩变化。强调了进行预防性医学检查以预防呼吸和/或免疫功能损害发展的必要性。
