Píriz Durán S, Kayser F H, Berger-Bächi B
Department of Medicine and Animal Health, Faculty of Veterinary Medicine, University of Extremadura, Cáceres, Spain.
FEMS Microbiol Lett. 1996 Aug 1;141(2-3):255-60. doi: 10.1111/j.1574-6968.1996.tb08394.x.
The global regulators agr and sar control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in the number of cells in the subpopulation expressing high methicillin resistance. The amount of low affinity penicillin-binding protein PBP2', the prerequisite for methicillin resistance, was apparently not affected, however, a reduction in PBP1 and PBP3 production was observed, suggesting that these resident PBPs of the cells might be involved somehow together with PBP2' in high level methicillin resistance.
全局调控因子agr和sar控制细胞壁蛋白和胞外蛋白的表达。在典型的异质性耐甲氧西林金黄色葡萄球菌中，sar和/或agr的失活导致表达高耐甲氧西林的亚群细胞数量出现小幅度但可重复的减少。低亲和力青霉素结合蛋白PBP2'是耐甲氧西林的前提条件，其数量显然未受影响，然而，观察到PBP1和PBP3的产量有所降低，这表明细胞中的这些固有青霉素结合蛋白可能以某种方式与PBP2'共同参与高水平的耐甲氧西林过程。
