Butorina O G, Donskova M D
Morfologiia. 1996;109(1):95-9.
Thymic peptides effect on the female gonad development was studied: consequences of these substances dysbalance in infancy (T-activine administration of 0.1 microgram/g of body weight in dose since 8 to 21 postnatal day) was analysed. Morphofunctional diagnostics of the ovarian state is based on the spontaneous organism reaction to the drug administration (to 21-days-old animals) and on the distant consequences of its activity (in 1-, 2-, 3-months female animals). Thymic peptides dysbalance in infancy promotes only transitory disorders of the ovarian histophysiology, expressing in transitory inhibition of the follicle genesis with the simultaneous atretic process activation, which results in puberty delay with the following complete restoration of reproductive function. Taking into account that in the early neonatal period gonad reacts to T-activine administration with the development of strong ovarian pathology, the results obtain allow to conclude that the reactivity to thymic peptides content oscillations reduces so as the significance of the factors cited in the ovarian morphogenesis regulation in proportion with the animals' maturity.
分析了婴儿期这些物质失衡的后果（自出生后第8天至21天，以0.1微克/克体重的剂量给予T-激活素）。卵巢状态的形态功能诊断基于机体对药物给药（对21日龄动物）的自发反应以及其活性的远期后果（在1、2、3月龄雌性动物中）。婴儿期胸腺肽失衡仅促进卵巢组织生理学的短暂紊乱，表现为卵泡发生的短暂抑制，同时伴有闭锁过程激活，这导致青春期延迟，随后生殖功能完全恢复。考虑到在新生儿早期，性腺对T-激活素给药的反应是发生严重的卵巢病变，所得结果表明，随着动物成熟，对胸腺肽含量波动的反应性降低，卵巢形态发生调节中所提及因素的重要性也相应降低。
