Alfonso S, Roquer J, Pou A
Servicio de Neurología, Hospital del Mar, Barcelona.
Neurologia. 1996 Jun-Jul;11(6):233-5.
A patient with recurrent-remittent multiple sclerosis associated with neurofibromatosis type I is described. The case is interesting for two reasons: 1) the difficulty of evaluating MRI findings, since both entities involve similar anomalies and 2) the relation between the two entities, according to evidence from recent genetic studies showing that the myelin protein gene associated to oligodendrocytes is part of an intron of the neurofibromatosis-1 gene of chromosome 17.
本文描述了一名患有复发缓解型多发性硬化症且伴有Ⅰ型神经纤维瘤病的患者。该病例之所以有趣,有两个原因:1)评估MRI结果存在困难,因为这两种疾病都涉及相似的异常情况;2)根据最近的基因研究证据,这两种疾病之间存在关联,该证据表明与少突胶质细胞相关的髓磷脂蛋白基因是17号染色体上神经纤维瘤病1基因内含子的一部分。