Su H R
Department of Stomatology, Medical University of South Carolina, Charleston, USA.
Int Arch Allergy Immunol. 1996 Aug;110(4):314-7. doi: 10.1159/000237322.
S-protein/vitronectin participates in the regulation of complement-mediated lysis by incorporating into the membrane attack complex C5b-9. Subsequently, soluble SC5b-7 and SC5b-9 macromolecules are not inserted into the membrane lipid bilayer nor induce lytic pore formation. Using a dot blot binding assay, it was determined that soluble S-protein/vitronectin interacted with immobilized C5b and C8 among the five separately immobilized components (C5b, C6, C7, C8, C9) of the membrane attack complex. Those interactions imply a new model of the formation of the complement membrane attack complex and its regulation by S-protein/vitronectin.
S 蛋白/玻连蛋白通过整合到膜攻击复合物 C5b-9 中参与补体介导的溶解调节。随后，可溶性 SC5b-7 和 SC5b-9 大分子既不插入膜脂双层，也不诱导溶细胞孔形成。使用斑点印迹结合试验确定，在膜攻击复合物的五个分别固定的组分（C5b、C6、C7、C8、C9）中，可溶性 S 蛋白/玻连蛋白与固定化的 C5b 和 C8 相互作用。这些相互作用暗示了补体膜攻击复合物形成及其受 S 蛋白/玻连蛋白调节的新模型。
