Villafranca J E, Kissinger C R, Parge H E
Agouron Pharmaceuticals Inc., La. Jolla, CA 92037, USA.
Curr Opin Biotechnol. 1996 Aug;7(4):397-402. doi: 10.1016/s0958-1669(96)80114-5.
In the past year, the three-dimensional structures of two serine/threonine phosphatases, protein phosphatase-1 and protein phosphatase-2b (calcineurin), have been determined. The new information puts previous sequence comparisons and mutagenesis studies into a detailed structural perspective. The active-site structure and catalytic mechanism appear to be common to a variety of phosphoesterase enzymes.
在过去的一年里，已经确定了两种丝氨酸/苏氨酸磷酸酶——蛋白磷酸酶-1和蛋白磷酸酶-2b（钙调神经磷酸酶）的三维结构。这些新信息将先前的序列比较和诱变研究置于详细的结构视角之下。活性位点结构和催化机制似乎是多种磷酸酯酶所共有的。
