Breaker R R
Department of Biology, Yale University, New Haven, CT 06520, USA.
Curr Opin Biotechnol. 1996 Aug;7(4):442-8. doi: 10.1016/s0958-1669(96)80122-4.
Progress in several areas of research is pushing back the supposed limitations of nucleic acid structure and function. New ligand-binding and catalytic RNAs are being created at a rapid pace. Some engineered RNAs offer potential as therapeutic agents whereas others can be used as model systems to study the principles that direct structure formation, molecular recognition and catalytic function by nucleic acids.
多个研究领域的进展正在突破核酸结构和功能的既定局限。新型配体结合RNA和催化RNA正迅速涌现。一些经过工程改造的RNA具有作为治疗剂的潜力,而其他一些则可作为模型系统,用于研究指导核酸结构形成、分子识别和催化功能的原理。