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Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?

作者信息

Christians U, Bleck J S, Lampen A, Bader A, Thiesemann C, Kliem V, Repp H, Westhoff-Bleck M, Manns M, Sewing K F

机构信息

Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Germany.

出版信息

Transplant Proc. 1996 Aug;28(4):2159-61.

PMID:8769186
Abstract
摘要

相似文献

1
Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?在稳定的男性和女性肾移植受者中，联合使用地尔硫䓬后，小肠中的细胞色素P450 3A酶是否是导致环孢素代谢产物模式不同的原因？
Transplant Proc. 1996 Aug;28(4):2159-61.
2
No gender-associated differences of cyclosporine pharmacokinetics in stable renal transplant patients treated with diltiazem.在用硫氮卓酮治疗的稳定肾移植患者中，环孢素的药代动力学不存在性别相关差异。
Transplant Proc. 2005 Oct;37(8):3364-6. doi: 10.1016/j.transproceed.2005.09.098.
3
Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients.地尔硫䓬可提高环化环孢素代谢物的血药浓度，导致稳定期男性和女性肾移植受者的环孢素代谢物模式不同。
Br J Clin Pharmacol. 1996 Jun;41(6):551-6. doi: 10.1046/j.1365-2125.1996.34412.x.
4
Clinical and medicoeconomic impact of the cyclosporine-diltiazem interaction in renal transplant recipients.环孢素与地尔硫䓬相互作用对肾移植受者的临床及药物经济学影响。
Pharmacotherapy. 1994 Jul-Aug;14(4):471-81.
5
Pharmacokinetic analysis of Neoral conversion in pediatric and adult renal transplant recipients with poor absorption of Sandimmune.
Transplant Proc. 1996 Aug;28(4):2165-8.
6
Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes.
Res Commun Chem Pathol Pharmacol. 1993 Nov;82(2):209-16.
7
Study of neoral kinetics in adult renal transplantation treated with diltiazem.地尔硫䓬治疗成人肾移植中他克莫司药代动力学的研究。
Transplant Proc. 1998 Aug;30(5):1660-2. doi: 10.1016/s0041-1345(98)00381-9.
8
Prediction of cyclosporine clearance in liver transplant recipients by the use of midazolam as a cytochrome P450 3A probe.使用咪达唑仑作为细胞色素P450 3A探针预测肝移植受者中环孢素的清除率。
Clin Pharmacol Ther. 2000 Mar;67(3):242-8. doi: 10.1067/mcp.2000.104642.
9
Limited sampling strategy to estimate exposure to cyclosporine A in renal allograft recipients treated with Sandimmune-Neoral.
Transplant Proc. 1996 Dec;28(6):3138-9.
10
Diltiazem modulates cyclosporin A induced renal hemodynamic effects but not its effect on plasma endothelin-1.
Clin Transplant. 1998 Oct;12(5):363-70.

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Antihypertensive treatment for kidney transplant recipients.肾移植受者的降压治疗。
Cochrane Database Syst Rev. 2024 Jul 31;7(7):CD003598. doi: 10.1002/14651858.CD003598.pub3.
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Antihypertensive treatment for kidney transplant recipients.肾移植受者的降压治疗
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Lack of sex-related differences in saquinavir pharmacokinetics in an HIV-seronegative cohort.在艾滋病病毒血清阴性队列中，沙奎那韦药代动力学不存在性别差异。
Br J Clin Pharmacol. 2006 Apr;61(4):379-88. doi: 10.1111/j.1365-2125.2006.02593.x.
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Mechanisms of clinically relevant drug interactions associated with tacrolimus.与他克莫司相关的临床显著药物相互作用机制。
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Cytochrome P450 3A: ontogeny and drug disposition.细胞色素P450 3A：个体发育与药物处置
Clin Pharmacokinet. 1999 Dec;37(6):485-505. doi: 10.2165/00003088-199937060-00004.
6
[Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients].[地尔硫䓬对接受山地明和新山地明治疗的肾移植患者中环孢素代谢物浓度的影响]
Med Klin (Munich). 1997 Oct 15;92(10):589-96. doi: 10.1007/BF03044784.