Katz S M, Amante A, Schoenberg L, Kahan B D
University of Texas Medical School at Houston 77030, USA.
Transplant Proc. 1996 Aug;28(4):2164.
A cohort of 11 patients receiving de novo CyA-GC was compared to 11 patients receiving CyA-ME immediately following renal transplantation at five-dose intervals in the first 30 postoperative days. Neither group achieved target CyA concentrations during days 0 to 2, suggesting that additional immunosuppression exposure coverage may be needed at that interval. Thereafter, however, recipients of the CyA microemulsion (Neoral) formulation reached target levels earlier as well as required lower doses to reach target levels.
将一组11例接受从头开始使用环孢素软胶囊（CyA-GC）治疗的患者与11例肾移植术后立即接受环孢素微乳剂（CyA-ME）治疗的患者进行比较，在后30天内按五剂间隔给药。在术后0至2天，两组均未达到环孢素的目标浓度，这表明在此期间可能需要额外的免疫抑制暴露覆盖。然而，此后，接受环孢素微乳剂（新山地明）制剂的受者更早达到目标水平，并且达到目标水平所需的剂量更低。
